Full Record |
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| Identifier | py0006 | ||
Creator |
Jackman, Robert W. |
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Title |
The molecular basis of skeletal muscle atrophy/Robert W. Jackman and Susan C. Kandarian |
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| Publication date | 2004 | ||
| Format | html and PDF | ||
| Series | Am J Physiol Cell Physiol 287: C834-C843, | ||
| Abstract |
"Skeletal muscle atrophy attributable to muscular inactivity has significant adverse functional consequences. While the initiating physiological event leading to atrophy seems to be the loss of muscle tension and a good deal of the physiology of muscle atrophy has been characterized, little is known about the triggers or the molecular signaling events underlying this process. Decreases in protein synthesis and increases in protein degradation both have been shown to contribute to muscle protein loss due to disuse, and recent work has delineated elements of both synthetic and proteolytic processes underlying muscle atrophy. It is also becoming evident that interactions among known proteolytic pathways (ubiquitin-proteasome, lysosomal, and calpain) are involved in muscle proteolysis during atrophy ". |
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| Contributor |
Kandarian, Susan C. |
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| Type |
Journal article |
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| System requirements |
Web browser and PDF reader |
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| Mode of Access |
No restriction to some full text articles |
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Subject |
Physiology | ||
Subject |
Muscle | Identifier URI |
http://ajpcell.physiology.org/cgi/content/full/287/4/C834 |
Remote access |
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